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Item number: TGM-T2673-100mg

Description: A 438079 hydrochloride (A-438079 HCl) is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9. Target: P2X Receptor. Smiles: Cl.Clc1cccc(-c2nnnn2Cc2cccnc2)c1Cl. References: McGaraughty S, et al. Neuroscience. 2007, 146(4), 1817-1828.

Keywords:	A 438079 (hydrochloride), A-438079 HCl, A-438079 hydrochloride
Application:	P2X7 antagonist
CAS	899431-18-6
MW:	342.61 D

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A-438079 (hydrochloride)

Item number: Cay14580-5

A-438079 is a competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9). It inhibits both calcium flux and IL-1beta release mediated by P2X7 while not affecting the activity of other P2X receptors. A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in...

Keywords:	3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-pyridine, monohydrochloride
Application:	P2X7 antagonist
CAS	899431-18-6
MW:	342.6 D

From 119.00€ *

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