3 products were found matching "898280-07-4"!
No results were found for the filter!
XL228
Item number: TGM-T17267-100mg
Description: XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). Target: Src, Bcr-Abl, Aurora Kinase, IGF-1R. Smiles: CC(C)c1cc(CNc2nc(Nc3cc([nH]n3)C3CC3)cc(n2)N2CCN(C)CC2)on1. References: Cortes J, et al. Preliminary...
| Application: | IGF1R / FGFR1-3 inhibitor |
| CAS | 898280-07-4 |
| MW: | 437.54 D |
From 51.00€
*
XL228
Item number: Cay21506-10
XL228 is a tyrosine kinase inhibitor. It inhibits the receptor tyrosine kinases insulin-like growth factor 1 receptor (IGF-1R) and FGFR2 (IC50s = 1.6 and 50s = 5, 3.1, 2, and 6.1 nM, respectively). XL228 inhibits proliferation of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines...
| Keywords: | N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-6-(4-methyl-1-piperazinyl)-2,4-pyrimidinedi... |
| Application: | IGF1R / FGFR1-3 inhibitor |
| CAS | 898280-07-4 |
| MW: | 437.5 D |
From 111.00€
*
XL-228
Item number: LKT-X4400.1
XL-228 is a third generation inhibitor of Abl that shows efficacy in a variety of cell lines, including those exhibiting T315I mutations. XL-228 displays anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for chronic myelogenous leukemia (CML).
| Application: | Abl inhibitor |
| CAS | 898280-07-4 |
| MW: | 437.54 D |
From 169.00€
*
