Description: DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 µM and 1.09 µM, respectively). Target: Histone Methyltransferase, DNA Methyltransferase. Smiles: OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12. References: Chen S, et al. Identifying novel selective non-nucleoside DNA...

DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1, IC50 = 10.3 µM). It is selective for DNMT1 over DNMT3A and DNMT3B (IC50s = >200 µM), as well as the additional methyltransferases G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50s = >150, >150, >150, >150, and 37.1 µM, respectively). DC-05 (2.5-10 µM) reduces...