Description: Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets. Target: SARS-CoV,...

E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 (Cay-10007963) and prodrug form of E-64c (Cay-10007964) that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and...

E64d is an inhibitor of cathepsins that exhibits neuroprotective activity. In vivo, E64d inhibits cathepsin D, decreasing brain amyloid- (A ) plaque formation. E64d inhibition of cathepsins also aggravates left ventricular dysfunction in animal models of myocardial infarction.

White to off-white powder. Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (5mg/ml). Chemical. CAS: 88321-09-9. Formula: C17H30N2O5. MW: 342.4. Aloxistatin [E-64d] is a cell permeable irreversible inhibitor of lysosomal and cytosolic cysteine proteases cathepsin B an L, calpain 1/2, papain and has diverse...