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Item number: TGM-T4680-100mg

Description: HC-067047 is a potent and selective TRPV4 antagonist that also inhibits the endogenous TRPV4-mediated response to 4alpha-PDH. Target: TRP/TRPV Channel. Smiles: Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F. References: Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder...

Keywords:	HC067047
Application:	TRPV4 antagonist
CAS	883031-03-6
MW:	471.51 D

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HC-067047

Item number: Cay20927-5

HC-067047 is a TRPV4 antagonist that reversibly inhibits currents through human, rat, and mouse TRPV4 orthologs (IC50s = 48, 133, and 17 nM, respectively). It is selective for TRPV4 over TRPV1, TRPV2, TRPV3, and TRPM8 channels. HC-067047 has been shown to increase functional bladder capacity and to reduce...

Keywords:	2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Application:	TRPV4 antagonist
CAS	883031-03-6
MW:	471.5 D

From 44.00€ *

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