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CFI-400437
CFI-400437

Item number: SYN-1207-M100

CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft...
Keywords: (E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one...
Application: Potent PLK4 inhibitor
CAS 882405-89-2
MW: 565.5 D
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BBT594
BBT594

Item number: SYN-1225-M001

BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase...
Keywords: BBT-594
Application: Potent, selective RET / JAK2 inhibitor
CAS 882405-89-2
MW: 569.6 D
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Review