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R-268712
Item number: TGM-T16708-100mg
Description: R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-beta type I receptor inhibitor. Target: ALK, TGF-beta/Smad. Smiles: Cc1cccc(n1)-c1n[nH]cc1-c1ccc(F)c(c1)-c1cnn(CCO)c1. References: Terashima H, et al. R-268712,...
| Application: | TGF-beta receptor type-1 (ALK5) inhibitor |
| CAS | 879487-87-3 |
| MW: | 363.39 D |
From 40.00€
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R-268712
Item number: Cay36810-10
R-268712 is an inhibitor of activin receptor-like kinase (ALK5, IC50 = 2.5 nM). It is selective for ALK5 over p38 MAPK (IC50 = 12 µM). R-268712 (1, 3, and 10 mg/kg) reduces renal fibrosis in a model of unilateral ureteral obstruction using transgenic Col1a1-Luc Tg rats, a reporter model for collagen I expression. It...
| Keywords: | 4-[2-fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol |
| Application: | TGF-beta receptor type-1 (ALK5) inhibitor |
| CAS | 879487-87-3 |
| MW: | 363.4 D |
From 36.00€
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