4 products were found matching "877399-52-5"!
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Crizotinib
Item number: TGM-T1661-100mg
Description: Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinase inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptors. Target: ROS Kinase, c-Met/HGFR, Autophagy, ROS, ALK. Smiles: O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N. References: Zou HY, et al. An...
| Keywords: | PF-02341066 |
| Application: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| CAS | 877399-52-5 |
| MW: | 450.34 D |
From 46.00€
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Crizotinib
Item number: LKT-C6935.5
A potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK).
| CAS | 877399-52-5 |
| MW: | 450.34 D |
From 141.00€
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(R)-Crizotinib
Item number: Cay12087-50
(R)-Crizotinib is a dual inhibitor of c-Met and anaplastic lymphoma kinase (ALK, IC50s = 8 and 20 nM, respectively, in a cell-based assay). It is selective for c-Met and ALK over several other receptor- and non-receptor tyrosine kinases, including Ron, Tie2, Abl, LCK, and VEGFR2 (IC50s = 0.08, 0.448, 1.159, 2.741,...
| Keywords: | PF 2341066, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Application: | c-Met /ALK inhibitor |
| CAS | 877399-52-5 |
| MW: | 450.3 D |
From 119.00€
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Crizotinib
Item number: CDX-C0699-M010
White to off-white powder. Soluble in choroform, DMSO or methanol. Chemical. CAS: 877399-52-5. Formula: C21H22Cl2FN5O. MW: 450.34. Synthetic. Crizotinib is an anticancer drug. It is a potent, orally bioavailable, ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor...
| Keywords: | (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, PF 2341066,... |
| CAS | 877399-52-5 |
| MW: | 450,34 D |
From 122.00€
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