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E 2012
Item number: TGM-T15184-10mg
Description: E2012 is a gamma-secretase modulator (GSM). E2012 inhibits 3beta-hydroxysterol Delta24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid beta-42, and induces cataract following repeated doses in the rat. Target:...
| Application: | gamma-secretase modulator |
| CAS | 870843-42-8 |
| MW: | 419.49 D |
From 34.00€
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E2012
Item number: Cay29710-10
E2012 is a modulator of gamma-secretase. It selectively inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta) over Notch cleavage to its signaling effector Notch intracellular domain (NICD), processes both mediated by gamma-secretase, when used at a concentration of 1 µM in luciferase...
| Keywords: | (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidinone |
| Application: | gamma-secretase modulator |
| CAS | 870843-42-8 |
| MW: | 419.5 D |
From 133.00€
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