Description: Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Target: Antibiotic, Antifungal, CRM1. Smiles:...

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...

Leptomycin B (LepB) is a potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. Solubility: Soluble in ethanol. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of...

An antifungal antibiotic, found to be a potent antitumor agent. It is suggested that the antitumor effect is related to cytochrome c release, activation of caspases, and selective down-regulation ofMc1-1 and XIAP. Leptomycin B has also been found to inactivate the export receptor CRM1. The effect of LepB on the...

LB Broth media formulations have been industry standards for the cultivation of Escherichia coli since the 1950's (1,2,3,4). These media have been widely used in molecular microbiology applications for the preparation of plasmid DNA and recombinant proteins (1,5). The media are nutrient-rich formulations which...