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GW280264X
Item number: TGM-T8961-100mg
Description: GW280264X (Carbamic acid) is an inhibitor of ADAM17 . Target: MMP. Smiles: CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)Nc1nccs1)N(O)C=O. References: Malemud C J . Inhibition of MMPs and ADAM/ADAMTS[J]. Biochemical Pharmacology, 2019.
| Keywords: | Carbamic acid |
| Application: | ADAM17/TACE inhibitor, ADAM10 inhibitor |
| CAS | 866924-39-2 |
| MW: | 575.72 D |
From 166.00€
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GW 280264X
Item number: Cay31388-1
GW 280264X is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17/TNF-alpha converting enzyme (ADAM17/TACE) and ADAM10 (IC50s = 8 and 11.5 nM, respectively). It inhibits TNF-alpha-induced cleavage of endomucin in human umbilical vein endothelial cells (HUVECs) when used at a concentration...
| Keywords: | N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]-carbamic... |
| Application: | ADAM17/TACE inhibitor, ADAM10 inhibitor |
| CAS | 866924-39-2 |
| MW: | 575.7 D |
From 166.00€
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