Description: Aftin-4, an amyloid forty-two inducer, activates gamma-secretase, promoting the generation of amyloid-beta-1-42 (Abeta1-42) from amyloid-beta protein precursor. Aftin-4(Aftin4) increased Abeta-1-42, but not Abeta-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial...

Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells....

Aftin-4 is an inducer of amyloid-beta (1-42) (Abeta42). It selectively increases extracellular Abeta42 over Abeta40 production in N2a-AbetaPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Abeta42 content, lipid peroxidation, and...