Description: LT175, a dual PPARalpha/gamma ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARgamma with EC50 values of 0.22 µm for hPPARalpha, 0.26 µm for mPPARalpha, and 0.48 µm for hPPARgamma. LT175 specifically interacts with...

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARalpha demonstrates a particular role in fatty acid oxidation whereas PPARgamma is known to be involved in adipocyte differentiation and lipid storage....