PF-00446687 is an agonist of melanocortin receptor 4 (MC4R). It selectively activates adenylyl cyclase in HEK293 cells expressing MC4R (EC50 = 0.012 µM) over HEK293 cells expressing MC1R, MC3R, or MC5R (EC50s = 1.02, 1.16, and 1.98 µM, respectively). PF-00446687 (1 mg/kg per day) increases time spent huddling and in...

Description: PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM). Target: Others. Smiles: C[C@H]1CN(C[C@@H](C)[C@]1(O)c1ccccc1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C. References: Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with...