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Degrasyn
Item number: TGM-T6300-100mg
Description: Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Target: JAK, Bcr-Abl, Apoptosis, Autophagy, DUB. Smiles:...
| Keywords: | WP1130 |
| Application: | Second-generation tyrphostin derivative, JAK2 signaling inhibitor, JAK2 ubiquitination inducer |
| CAS | 856243-80-6 |
| MW: | 384.27 D |
From 57.00€
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WP1130
Item number: Cay15227-10
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into two subgroups: ubiquitin-specific proteases (USPs) and ubiquitin-specific COOH-terminal hydrolases...
| Keywords: | Degrasyn, (2E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[1S-phenylbutyl]-2-propenamide |
| Application: | Tyrphostin derivate, Deubiquitinase activity inhibitor |
| CAS | 856243-80-6 |
| MW: | 384.3 D |
From 92.00€
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WP1130
Item number: AG-CR1-3551-M001
WP1130 is a second-generation tyrphostin derivative initially identified as a JAK2 signaling inhibitor through JAK2 ubiquitination that reduces STAT activation stimulated by cytokines (such as IL-6 and IL-3) through the rapid down-regulation of upstream JAK kinases. WP1130 has also been identified as a partially...
| Keywords: | WPI 130, Degrasyn, (2E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide |
| Application: | Second-generation tyrphostin derivative, JAK2 signaling inhibitor, JAK2 ubiquitination inducer |
| CAS | 856243-80-6 |
| MW: | 384,3 D |
From 33.00€
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