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Ponesimod
Item number: TGM-T3258-100mg
Description: Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. Target: S1P Receptor, LPL Receptor. Smiles: CCC\N=C1/S\C(=C/c2ccc(OC[C@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C. References: Piali L. et al. J Pharmacol Exp Ther....
| Keywords: | ACT-128800 |
| Application: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 854107-55-4 |
| MW: | 460.97 D |
From 40.00€
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Ponesimod
Item number: Cay22053-1
Ponesimod is a potent agonist of sphingosine-1-phosphate receptor 1 (S1P1/EDG-1, IC50s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P1-S1P5, respectively, in a radioligand binding assay). It selectively activates S1P1 in a GTPgammaS assay (EC50s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P1-S1P5, respectively)....
| Keywords: | (2Z)-5Z-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-4-thiazolidinone |
| Application: | S1P(1) agonist |
| CAS | 854107-55-4 |
| MW: | 461 D |
From 53.00€
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