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(±)-Necrostatin-2
(±)-Necrostatin-2

Item number: Cay20924-1

(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner. Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS)....
Keywords: 7-Cl-O-Nec-1, Nec-1s, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
Application: Cell-permeable RIP1 inhibitor
CAS 852391-15-2
MW: 277.7 D
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