Description: CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERalpha, MGRERalpha, hERalpha and hERbeta, respectively. Target: Estrogen/progestogen Receptor, Estrogen...

CMP8 is a mutant estrogen receptor alpha (ERalpha) antagonist and ligand used for bump and hole, a technique to study single protein isoforms when familial homology would interfere with other isoform-selective approaches. It is selective for an ERalpha triple mutant containing a lysine-to-methionine substitution at...