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Item number: Cay34801-100

Brevetoxin 3 is a neurotoxin produced by the dinoflagellate K. brevis. It binds to site 5 of voltage-gated sodium channels (Navs), prolonging the mean open time and inhibiting inactivation of these channels. Brevetoxin 3 induces the release of lactate dehydrogenase (LDH), L-glutamate, and L-aspartate from primary...

Keywords:	PbTx-3, T-17 Toxin, 42-deoxo-42-hydroxy-brevetoxin B
Application:	Neurotoxin
CAS	85079-48-7
MW:	897.1 D

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Brevetoxin 3

Item number: LKT-B6918.1

Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening effect, this activity results in...

Keywords:	PbTx-3
Application:	SCN4A/Nav1.4 / SCN5A/Nav1.5 agonist
CAS	85079-48-7
MW:	897.2 D

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