Description: Brevetoxin-3 (PbTx-3) is a potent allosteric activator of voltage-gated Na+ channels, exhibiting a high affinity for site 5 and inhibiting the inactivation of these channels. Target: Others. Smiles:...

Brevetoxins are lipid-soluble polyether neurotoxins produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening effect, this activity results in...

Brevetoxin 3 is a neurotoxin produced by the dinoflagellate K. brevis. It binds to site 5 of voltage-gated sodium channels (Navs), prolonging the mean open time and inhibiting inactivation of these channels. Brevetoxin 3 induces the release of lactate dehydrogenase (LDH), L-glutamate, and L-aspartate from primary...