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Item number: Cay11492-5

Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces...

Keywords:	BIBW 2992,...
Application:	EGFR / HER2 kinase inhibitor
CAS	850140-72-6
MW:	485.9 D

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Afatinib, Free Base (BIBW-2992, Giotrif, Gilotrif, Tovok,...

Item number: LC-A-8644_1g

Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 50-100 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility

Application:	Tyrosine kinase inhibitor
CAS	850140-72-6
MW:	485,94 D

From 91.00€ *

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