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RO4929097
Item number: TGM-T6274-100mg
Description: RO4929097 (RG-4733), a gamma secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Abeta40 and Notch (EC50: 14/5 nM). Target: Gamma-secretase, Beta Amyloid. Smiles: CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2ccccc2NC1=O. References: Luistro L, et al. Preclinical profile of a potent...
| Keywords: | RG-4733 |
| Application: | Potent gamma-secretase inhibitor |
| CAS | 847925-91-1 |
| MW: | 469.4 D |
From 40.00€
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Ro 4929097
Item number: Cay19996-500
Ro 4929097 is a potent inhibitor of gamma-secretase (IC50 = 4 nM) that blocks both Abeta40 and Notch processing (IC50s = 14 and 5 nM, respectively). It displays greater than 100-fold selectivity for gamma-secretase over a panel of 75 other enzymes, receptors, and ion channels. Ro 4929097 does not block tumor cell...
| Keywords: | N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-propanediamide |
| Application: | Potent gamma-secretase inhibitor |
| CAS | 847925-91-1 |
| MW: | 469.4 D |
From 44.00€
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