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A-769662
Item number: Cay11900-5
A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates beta1 subunit-containing AMPK heterotrimers, and its effects are independent...
| Keywords: | 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Application: | AMPK activator |
| CAS | 844499-71-4 |
| MW: | 360.4 D |
From 94.00€
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![A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-car](https://www.biomol.com/media/image/7d/84/20/A0001-68U-10_200x200.jpg "A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-car")
A-769662...
Item number: A0001-68U.10
A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alpha beta gamma heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the B1 subunit. A-769662 activates AMPK through the beta...
| CAS | 844499-71-4 |
| MW: | 360.39 |
263.00€
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A-769662
Item number: LKT-A2420.10
AMPK activator
| Application: | AMPK activator |
| CAS | 844499-71-4 |
| MW: | 360.39 D |
From 183.00€
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A-769662
Item number: TGM-T2468-100mg
Description: A-769662 is an effective, reversible AMPK activator(EC50=0.8 µM). Target: AMPK, Fatty Acid Synthase. Smiles: Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12. References: Cool B, et al, Cell Metab, 2006, 3(6), 403-416.
| Keywords: | A 769662 |
| Application: | AMPK activator |
| CAS | 844499-71-4 |
| MW: | 360.39 D |
From 34.00€
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