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Item number: TGM-T4060-100mg

Description: Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine. Target: DNA/RNA Synthesis. Smiles: FC1(F)[C@@H](O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)[C@H]1O)N4C(=O)N=C(N)C=C4. References: Slusarczyk M, et al. Application of ProTide...

Keywords:	NUC-1031
Application:	Gemcitabine prodrug
CAS	840506-29-8
MW:	580.47 D

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NUC-1031

Item number: Cay9003247-1

NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Cay-11690). NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion. It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively). NUC-1031 (0.076...

Keywords:	N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester
Application:	Gemcitabine prodrug
CAS	840506-29-8
MW:	580.5 D

From 52.00€ *

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