Description: Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces apoptosis. Target: p53, Autophagy, Mitochondrial Metabolism, Apoptosis,...

Rotenone is a classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC50 values of 28.8 and 5.1 nM, respectively. In substantia nigra pars compacta neurons, it activates ATP-sensitive potassium channels and increases the production of...

Synthetic. Originally isolated from Lonchocarpus nicou. White to off-white solid. Soluble in DMSO (20mg/ml), ethanol (1mg/ml) or chloroform (20mg/ml). Cell-permeable reversible and competitive mitochondrial electron transport chain complex I (NADH-CoQ reductase) inhibitor (IC50=1.7-2.2?M). Inhibits NADH/DB...

Rotenone is an odorless chemical that is used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the roots and stems of several plants such as the jicama vine plant.