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Item number: Cay23511-10

Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 µM), porcine dipeptidase (IC50 = 0.11 µM), and bacterial metallo-beta-lactamase CphA from A. hydrophila (IC50 = 178 µM). Cilastatin (200 µg/ml) protects primary porcine renal proximal...

Keywords:	(2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
Application:	Dipeptidase 1 (DPEP1) inhibitor
CAS	82009-34-5
MW:	358.5 D

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Cilastatin

Item number: TGM-T2583-100mg

Description: Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also...

Keywords:	MK0791
Application:	Targets membrane dipeptidase [EC:3.4.13.19] (DPEP)
CAS	82009-34-5
MW:	358.45 D

From 31.00€ *

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