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Obatoclax Mesylate
Item number: TGM-T6275-100mg
Description: Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 µM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3. Target: Autophagy, Parasite, BCL. Smiles: CS(O)(=O)=O.COc1cc([nH]c1=Cc1[nH]c(C)cc1C)=C1C=c2ccccc2=N1. References: Nguyen M,...
| Keywords: | GX15-070, Obatoclax |
| Application: | Targets apoptosis regulator Bcl-2 (BCL2) |
| CAS | 803712-79-0 |
| MW: | 413.49 D |
From 43.00€
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Obatoclax (mesylate)
Item number: Cay11499-1
Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and...
| Keywords: | GX15-070, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate |
| Application: | Antagonist of Bcl-2 family members containing four Bcl-2 homology domains |
| CAS | 803712-79-0 |
| MW: | 413.5 D |
From 85.00€
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