Description: Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 µM) and p300/CPB-associated factor (PCAF, IC50 = 5 µM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards...

Garcinol is a polyisoprenylated benzophenone that has been found in G. indica and has diverse biological activities. It inhibits the histone acetyltransferases (HATs) p300 and p300/CREB-binding protein-associated factor (PCAF, IC50s = ~7 and ~5 µM, respectively), as well as COX-1, microsomal prostaglandin E2 (PGE2)...