Description: RGB-286147 is a potent, selective, ATP-competitive Cdks inhibitor. Target: Others. Smiles: C(C)(C)C=1C2=C(N(N1)C3=C(Cl)C=CC=C3Cl)NC(CC4=CC=C(OCCO)C=C4)=NC2=O. References: Caligiuri M, Becker F, Murthi K, Kaplan F, Dedier S, Kaufmann C, Machl A, Zybarth G, Richard J, Bockovich N, Kluge A, Kley N. A...

CDK/CRK inhibitor is an inhibitor of cyclin-dependent kinases (CDK) and CDK-related kinases (CRK) with IC50 values ranging from 9-839 nM in vitro. It is selective, exhibiting less than 20% inhibition of 60 non-CDK/CRK kinases, at a concentration of 1 µM. CDK/CRK inhibitor induces cell cycle arrest in the G1 phase,...