Description: Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor. Target: PDE. Smiles: CC1=C(C=C(C#N)C(=O)N1)C=2C=CN=CC2. References: Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.

A selective phospodiesterase 3 inhibitor known to effect left ventricular relaxation by inhibiting the breakdown of cAMP in association with an acceleration of sarcoplasmic reticulum Ca(2)-ATP activity and CA(2) uptake. It inhibits platelet aggregation and induces disaggregation.

Milrinone is an inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1 µM, respectively. It is selective for PDE3 over PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 263, >300, 17.5, 49.1, and 58.3 µM, respectively). Milrinone (0.1-1 mg/kg) has positive...