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GNF-2
Item number: Cay16253-1
GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM. It inhibits proliferation of Ba/F3 cells (IC50 = 138 nM). GNF-2 (10 µM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus,...
| Keywords: | Bcr-Abl Inhibitor, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide |
| Application: | Bcr-abl inhibitor |
| CAS | 778270-11-4 |
| MW: | 374.3 D |
From 128.00€
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GNF-2
Item number: LKT-G5320.1
GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive, and anti-osteoporotic activities. GNF-2 shows potential benefit in the treatment of Philadelphia chromosome-positive acute myelogenous leukemia (ALL). In vitro, GNF-2 inhibits differentiation of osteoclasts, activity of...
| Application: | Bcr-abl inhibitor |
| CAS | 778270-11-4 |
| MW: | 374.32 D |
From 156.00€
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