Description: Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension. Target: Calcium Channel. Smiles: C(OC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C#N)C2=CC(N(=O)=O)=CC=C2. References: Nomoto A, et al. Atherosclerosis, 1988, 72(2-3), 213-219.

Nilvadipine is a dihydropyridine L-type calcium channel blocker. It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 µM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in...