Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3, EC50 = 3 nM). It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type...

Description: Psora-4 is a potent and selective inhibitor of K_v 1.3 (voltage-gated potassium channels) with a Hill coefficient of 2 and an EC50 value of 3 nM [1]. It exhibits immunosuppressive activity and inhibits the proliferation of human and rat myelin-specific effector memory T cells in vitro [2]. Target:...