Description: SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevents glutamate-induced neuronal death. It also increases levels of CALB1 gene expression in cerebrocortical neurons and triggers phosphorylation...

SUN11602 is a mimetic of FGF2, also known as basic FGF (bFGF). It protects against glutamate-induced toxicity in primary rat cortical neurons when used at concentrations of 0.1, 0.3, and 1 µM, an effect that can be reversed by the FGFR1 inhibitor PD 166866 (Cay-22464). SUN11602 (1 µM) stimulates neurite outgrowth in...