Description: 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of...

5-hydroxy Diclofenac is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor diclofenac (Cay-70680, Cay-22983). It is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2C19, and CYP1A2. 5-hydroxy Diclofenac is cytotoxic to HL-60 leukemia cells (IC50 = 661 µM). It...

A metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound an cyclooxygenase (COX) inhibitor. Melting Point: 175-178ºC, Solubility: Acetone, DMSO, Method for determining Identity: Proton NMR Spectroscopic Analysis, TLC Conditions: SiO2: Hexane: Ethyl Acetate: Acetic Acid, 1ml: 2ml: 1drop, Visulaized...

Metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound that functions via inhibiton of cyclooxygenase (COX). Diclofenac undergoes biotransformation not only by glucuronidation, but also by cytochrome P450-mediated oxidation to produce 4'-OH-DFN and 5-OH-DFN, which undergo subsequent oxidation to form...