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IWP-4
IWP-4

Item number: TGM-T4245-100mg

Description: IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor. Target: Wnt/beta-catenin. Smiles: COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O. References: Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling....
Keywords: Inhibitor of Wnt Production-4
Application: Wnt production inhibitor, porcupine inactivator
CAS 686772-17-8
MW: 496.62 D
From 42.00€ *
Review
IWP-4
IWP-4

Item number: Cay13954-1

IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM. IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 µM, IWP-4 has been shown to...
Keywords: Inhibitor of Wnt Production-4,...
Application: Wnt production inhibitor, Porcupine inactivator
CAS 686772-17-8
MW: 496.6 D
From 49.00€ *
Review