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Item number: Cay10005189-5

PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1alpha in cancer cells, resulting in reduced expression of HIF-1alpha target genes. It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1alpha level. PX-478 can also increase chemo- or...

Keywords:	4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine, dihydrochloride
Application:	HIF-1 alpha inhibitor
CAS	685898-44-6
MW:	394.1 D

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