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Item number: TGM-T7860-100mg

Description: SM-324405 is an agonist of TLR7. Target: TLR. Smiles: CCCCOc1nc(N)c2[nH]c(=O)n(Cc3cccc(CC(=O)OC)c3)c2n1. References: Kurimoto A, Hashimoto K, Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010...

Keywords:	SM 324405
Application:	TLR7 agonist
CAS	677773-91-0
MW:	385.42 D

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SM-324405

Item number: Cay29457-1

SM-324405 is a toll-like receptor 7 (TLR7) agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor). It is selective for TLR7 over TLR8 (EC50 = >10 µM). SM-324405 induces IFN production in isolated human peripheral blood mononuclear cells (PBMCs) with a minimum effective...

Keywords:	3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-benzeneacetic acid, methyl ester
Application:	TLR7 agonist
CAS	677773-91-0
MW:	385.4 D

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