Description: Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2, reducing fatty acid metabolism, with IC50 values of 77 µM and 148 µM against rat heart and liver CPT1, respectively. Target: Mitochondrial Metabolism, Others. Smiles: OC(=O)\C=C\C(O)=O.C(C(C1CCCCC1)C1CCCCC1)C1CCCCN1. References:...

Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM). Inhibition of CPT reduces uptake of long-chain fatty acids into...