Description: Strophanthidin (Strophanthidine) can induce calcium overload in vivo. Target: Calcium Channel, ATPase. Smiles: C[C@]12CCC3[C@@H](CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]1(O)CC[C@@H]2C1=CC(=O)OC1. References: The antiarrhythmic effect of potassium and rubidium in strophanthidin toxicity. European Journal...

Strophanthidin is a cardenolide that has been found in A. schimperi and has diverse biological activities. It is an inhibitor of N-acetyltransferase (IC50 = ~1.2 µM). Strophanthidin (1 µM) reduces maximal Na+/K+-ATPase pump activity and cell attachment and increases cell death in MDCK-C7 cells. It decreases the...