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Item number: Cay39520-1

NCI 126224 is a toll-like receptor 4 (TLR4) antagonist. NCI 126224 selectively inhibits nitric oxide (NO) production induced by the TLR4 agonist LPS (IC50 = 0.31 µM) over the TLR7/8 agonist R-848 (Cay-14806), TLR1/2 agonist Pam3CSK4 (Cay-24126), and TLR3 agonist poly(I:C) in RAW 264.7 macrophages but also inhibits...

Keywords:	NSC 126224, 2-[(2-nitrophenyl)methylene]-propanedioic acid, 1,3-dimethyl ester
Application:	TLR4 antagonist
CAS	65974-52-9
MW:	265.2 D

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