Description: SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRbeta, EGFR or Tie2. Target: Apoptosis, c-Met/HGFR, CDK, Autophagy, VEGFR, FGFR. Smiles: C(=C\1/C=2C(NC1=O)=CC=C(S(N(C)C3=CC(Cl)=CC=C3)(=O)=O)C2)\C4=C(C)C(C(=O)N5CCN(C)CC5)=C(C)N4....

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less...