Description: 3beta-hydroxy-5-Cholestenoic Acid is one of the metabolites of cholesterol found in high concentrations (40-80 ng/ml) in human circulation. Target: Others. Smiles: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C(O)=O)C)C)[H])[H]

3beta-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3beta-hydroxy-5-Cholestenoic acid is a modulator of gamma-secretase that decreases amyloid beta (1-42) peptide (Abeta42, EC50 = 250 nM) and increases Abeta38...