Description: SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker. Target: ADC Linker, Others. Smiles: O=C(ON1C(=O)CCC1=O)C1CCC(CN2C(=O)C=CC2=O)CC1. References: Li F, Wang Z, Huang Y, Xu H, He L, Deng Yan, Zeng X, He N. Delivery of PUMA Apoptosis Gene Using...

SMCC is a non-cleavable and membrane permeable crosslinker with a spacer arm of 8.3_angstrom.that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls.

SMCC is a heterobifunctional cross-linking reagent that contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. It has been used to cross-link the anticancer agent DM1 (mertansine, Cay-22483) to an IgG1 monoclonal antibody to...