Description: R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor. Target: Dehydrogenase. Smiles: Oc1c(CC=C)ccc2C(=O)c3ccccc3C(=O)c12. References: Jin L, et al. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015...

R162 is an inhibitor of glutamate dehydrogenase 1 (GDH1, IC50 = 23 µM). It decreases intracellular fumarate levels and increases the production of mitochondrial reactive oxygen species (ROS) in human H1299 lung and MDA-MB-231 breast cancer cells. R162 (10-40 µM) inhibits proliferation in a panel of human cancer cell...