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Item number: TGM-T20533-100mg

Description: NNK (Nicotine-derived nitrosamine ketone) is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor. Target: Lipoxygenase. Smiles: CN(CCCC(=O)c1cccnc1)N=O. References: Cheng G, Li J, Zheng M, Zhao Y, Zhou J, Li W. NNK, a...

Keywords:	Nicotine-derived nitrosamine ketone
CAS	64091-91-4
MW:	207.23 D

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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

Item number: Cay16414-10

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific nitrosamine carcinogen. Reactive metabolites of NNK alkylate DNA, forming pyridyloxobutyl (POB) and pyridylhydroxybutyl (PHB) adducts, and induce DNA methylation. NNK (100 mg/kg, single dose) increases the protein levels of DNA...

Keywords:	NNK, 4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
Application:	Tobacco-specific nitrosamine carcinogen
CAS	64091-91-4
MW:	207.2 D

From 117.00€ *

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