Description: Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPA MIDE. Target: Autophagy, Potassium Channel. Smiles: S(NC(NCCCC)=O)(=O)(=O)C1=CC=C(C)C=C1. References: Wray HL, et al, Biochem Biophys Res Commun. 1973, 53(1), 291-294.

Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx...