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Item number: Cay19888-50

Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx...

Keywords:	D 860, NSC 23813, NSC 87833, U-2043, N-[(butylamino)carbonyl]-4-methyl-benzenesulfonamide
Application:	ABCC8 inhibitor
CAS	64-77-7
MW:	270.3 D

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