Description: N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors. Target: NMDAR, Endogenous Metabolite, iGluR. Smiles: CN[C@H](CC(O)=O)C(O)=O. References: Cull-Candy S, et al. Curr Opin Neurobiol,...

NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate. Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity. Repetitive activation of NMDA synapses leads to long-term...