Description: BW-180C (DADLE) is a prototypical delta-opioid receptor agonist that also displays activity at the µ-opioid receptor. Displays antinociceptive activity in vivo. Target: Opioid Receptor. Smiles: [C@H](CC1=CC=CC=C1)(C(N[C@H](CC(C)C)C(O)=O)=O)NC(CNC([C@H](NC([C@H](CC2=CC=C(O)C=C2)N)=O)C)=O)=O. References:...

DADLE is a peptide agonist of delta-opioid receptors (Ki = 2.06 nM in a radioligand binding assay). It is selective for delta-opioid over kappa-opioid receptors (Ki = 16,000 nM) but also agonizes µ-opioid receptors (Ki = 13.8 nM). DADLE inhibits electrically induced contractions in guinea pig myenteric plexus and...