8 products were found matching "62996-74-1"!

A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...

Description: Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis. Target: Antifungal, PKC, Src, Antibacterial, Apoptosis, Antibiotic,...

Isolated from Streptomyces spiralis. Antibiotic. Antifungal and anti-yeast activity. Inhibits platelet aggregation induced by collagen or ADP. Has no effect on thrombin-induced platelet aggregation. Potent, cell permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein...

Staurosporine is a potent and cell-permeable inhibitor of a wide variety of protein kinases including protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM). Staurosporine induces apoptosis in human neuroblastoma cells and chick embryonic neurons.,Soluble in DMSO or...

Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurospores and is a super-potent, cell permeable PKC inhibitor (IC50=0.7), at higher concentrations Staurosporine inhibits other protein kinases: CDK2/cyclin A (IC50=7uM) and CDK4/cyclin D (IC50=3-10uM). At a concentration of 50-100nM it...

Staurosporine is a potent inhibitor of many kinases including protein kinase C, protein kinase A, and protein kinase G. It also induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons.