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Item number: Cay15373-1

Transcriptional activation by NF-kappaB is limited by IkappaBalpha binding, which masks the NF-kappaB nuclear localization signal that initiates nuclear translocation. Cytokines trigger a signaling cascade of kinases that target IkappaBalpha for degradation, enabling NF-kappaB to promote gene expression. Because...

Keywords:	6-(phenylsulfinyl)-tetrazolo[1,5-b]pyridazine
Application:	IkappaBalpha ubiquitination inhibitor
CAS	62645-28-7
MW:	245.3 D

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